Background: We cover why cefepime (and other beta-lactam antibiotics) can cause neurotoxicity. National Library of Medicine Patients were excluded if they met any of the following exclusion criteria: (1) Enterobacteriaceae with a cefepime disk diffusion diameter 18 mm; (2) polymicrobial bacteremia (ie, bloodstream infection with >1 organism); (3) cefepime discontinued <72 hours after the initial dose; (4) combination antimicrobial therapy; (5) death <48 hours Thank you for joining us on this Abstracts of Presentations at the Association of Clinical Scientists 143. DM Learn about why cryptococcal meningitis can cause such severe elevations in intracranial pressure, while often causing only minimal inflammation. Although the world is becoming mostly sedentary, our bodies still require a wide variety of daily movements in order to work well. Check out Avi's tweetorial on this topic as well. The Curious Clinicians learn about why Wenckebach heart block has such a unique morphology. Episode 4: Why did Van Gogh paint with so muchyellow? Join us to explore these questions and many more. To determine the independent predictors associated with mortality and microbiological failure, we performed multivariable logistic regression analyses. GA Hannah, Avi and Tony examine why we feel cold while febrile (shouldn't we feel hot?) Thank you for joining us on this medical curiosity journey and thank you to the team that has helped take the podcast to the next level, including audio editor extraordinaire Clair Morgan from Nodderly and the VCU Health Continuing Education team! , Liu J, McLaughlin MM, et al. P value was calculated using chi-square, Fisher exact, univariable logistic regression, or Kruskal-Wallis test, as appropriate. Read the show notes here. Password must be between 8 and 16 characters and contain the following: Curious Clinicians Episode 64 - Stopping the Shakes, Sunday, March 5, 2023, - Thursday, March 5, 2026, 11:00 PM, Curious Clinicians Episode 62 - Connected Bilirubin, Friday, February 17, 2023, - Tuesday, February 17, 2026, 11:00 PM, Curious Clinicians Episode 63 - Getting Swol, Curious Clinicians Episode 61 - Of ticks, alpha-gal, and red meat allergies, Thursday, December 8, 2022, - Monday, December 8, 2025, 11:00 PM, Curious Clinicians Episode 60 - Salty Hearts, Friday, November 18, 2022, - Tuesday, November 18, 2025, 11:00 PM, Curious Clinicians Episode 59 - Hyperkalemic Heparin, Thursday, October 13, 2022, - Monday, October 13, 2025, 11:00 PM, Curious Clinicians Episode 58 - Gutting a Pearl, Wednesday, September 28, 2022, - Sunday, September 28, 2025, 11:00 PM, Curious Clinicians Episode 57 - The Acetabular Ache, Monday, September 19, 2022, - Friday, September 19, 2025, 11:00 PM, Curious Clinicians Episode 56 - Trigging out, Thursday, September 1, 2022, - Monday, September 1, 2025, 11:00 PM, Curious Clinicians Episode 55 - A Cute Pigment, Tuesday, August 23, 2022, - Saturday, August 23, 2025, 11:00 PM, Sign in with your VCU Health Login (VCUHS Staff), Sign in with your email and password | Create new account, Must be between 8 and 16 characters in length, Must Contain at least 1 upper case character, Must Contain at least 1 lower case character, Must contain at least 1 numeric character, Must contain at least 1 of the following ! Patients were excluded if they met any of the following exclusion criteria: (1) Enterobacteriaceae with a cefepime disk diffusion diameter 18 mm; (2) polymicrobial bacteremia (ie, bloodstream infection with >1 organism); (3) cefepime discontinued <72 hours after the initial dose; (4) combination antimicrobial therapy; (5) death <48 hours after the initial cefepime dose; or (6) missing or duplicate data. Brief Summary: Multi-center, randomized, double-blind, non-inferiority study of cefepime 2 g/AAI101 500 mg combination compared to piperacillin 4 g/tazobactam 500 mg in a population of adult patients with cUTI or AP. Despite a large cohort, only 26 cases of cefepime-SDD Enterobacteriaceae were identified due to its infrequency. bIncluded Cedecea species (1), Citrobacter koseri (4), Citrobacter youngae (1), Cronobacter sakazakii complex (1), Enterobacter cancerogenus (1), Enterobacter species (1), Hafnia alvei (1), Klebsiella species (1), Kluyvera species (1), Leclercia species (1), Pantoea agglomerans (1), Pantoea species (6), Proteus vulgaris (1), Providencia stuartii (1), and Serratia liquefaciens (2). The impact of the revised Clinical and Laboratory Standards Institute interpretative criteria for cefepime in Enterobacteriaceae remains unclear. Do you miss digging into the why behind what we do every day in medicine? Google Play Store. On this episode of The Curious Clinicians, they explore that question and many more fun facts about this age old anticoagulant. Read the show notes here. Read the show notes here. Episode 33: How does Sinemets name provide insights into why it was developed and its mechanism ofaction? Join us to explore these questions and many more. Tony appeared as a guest on the Bedside Rounds podcast with Adam Rodman. The episode opens with an important message from Dr. Mark Shapiro (host of the Explore The Space podcast) about VoteHealth 2020. Audio edited by Clair Morgan of nodderly.com. Hannah examines theories as to why septic pulmonary emboli often present in the periphery and bases of the lungs, while "bland" pulmonary do not. Review our. Click hereto obtainAMA PRA Category 1 Credits(1.00 hours), Non-Physician Attendance (1.00 hours), or ABIM MOC Part 2 (1.00 hours). For full access to this pdf, sign in to an existing account, or purchase an annual subscription. NY Y Hannah, Tony, and Avi dig into the origins and mechanism of that most wondrous of flavors: umami. They inspect together why certain rashes have an acral distribution. On this episode of The Curious Clinicians, they explore that question and many more fun facts about this age old anticoagulant. Escherichia coli (32.5%) was the most commonly isolated Enterobacteriaceae, followed by Klebsiella pneumoniae (28.3%), and Enterobacter cloacae complex (13.3%). Association between gut microbiota and delirium in acutely ill older adults. , Lee CC, Huang WH, et al. Why does the human body function as it does? This site needs JavaScript to work properly. Episode 32: Why do eosinophils vanish from the blood after treatment with corticosteroids? On this episode the Curious Clinicians investigate why corticosteroids often cause blood eosinophil counts to drop so quickly and dramatically. Episode 30: Why do some people taste soap when they eatcilantro? In this episode The Curious Clinicians investigate why some people absolutely love cilantro while others taste soap if they try to eat it. Hannah explores whether disseminated intravascular coagulation (DIC) can itself be a source of shock. Abbreviations: aOR, adjusted odd ratio; CI, confident interval; CrCl, creatinine clearance; ESBL, extended-spectrum beta-lactamases; IQR, interquartile range; SDD, susceptible dose-dependent; SSI, surgical site infection. Bacteremia was classified into community- or nosocomial-acquired, defined as the first positive blood culture in <48 hours or 48 hours after hospitalization, respectively. An Elixhauser comorbidity index of 3 (adjusted odd ratio [aOR], 2.36; 95% confidence interval [CI], 1.194.69) and sepsis (aOR, 2.44; 95% CI, 1.404.24) were independently associated with 30-day all-cause mortality (Table 1). Hannah, Avi, and Tony break down why cancer leads to a hypercoagulable state, recalling the story of Armand Trousseau and exploring the roles of tissue factor and evading the immune system. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. 8600 Rockville Pike How can we move morea lot morewhen we have sore, stiff parts and overly busy lifestyles? Check out the show notes here. She loves learning about medicine and why we do what we do. On this episode Tony explores the benefits of fevers, including why even trees and bees mount fevers in response to infection. Click hereto obtainAMA PRA Category 1 Credits(0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 h, Why can heparin cause hyperkalemia? Doom and Bloom,Nurse Amy,Dr Bones,Survival,Survival Medicine,Traditional and Alternative Medical Advice including Survival Medicine or Collapse Medicine. Unauthorized use of these marks is strictly prohibited. Check out the show notes for this episode here. Cefepime is used to treat a wide variety of bacterial infections. This is the second episode in a two-part series called "The Eyes Have It", where The Curious Clinicians explore questions related to the eye. Remember to pick CME/MOC credit just for listening to the episode! In this episode, The Curious Clinicians investigate why tricuspid valve endocarditis is more common in persons who inject IV drugs. This medicine is given by injection or IV infusion (slow drip through a needle into a large N/A, VA. Curriculum: Check out Tony's companion tweetorial here. 2023;18(1):69-78. doi: 10.2174/1574886317666220309090408. Ranks), Assistant Professor in the Section of Infectious Disease, AmpC -lactamase-producing organism, No. In this reboot of episode 30, The Curious Clinicians investigate why some people absolutely love cilantro while others taste soap if they try to eat it. The Curious Clinicians examine why the nervous system is cross-wired, with each side of the brain controlling the opposite side of the body. Altshuler Click hereto obtainAMA PRA Category 1 Credits(0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy. ! We cover why cefepime (and other beta-lactam antibiotics) can cause neurotoxicity. Thank you for joining us on Does that crossing serve a purpose? Univariable and Multivariable Logistic Regression Predicting 30-Day All-Cause Mortality and Microbiological Failure Among 644 Patients With Enterobacteriaceae Bacteremia. Avi, Hannah, and Tony investigate why myocardial infarctions lead to ST elevations (and/or ST depressions) on EKG. In this episode, The Curious Clinicians examine why weight training increases muscle size. Copyright 2023 Apple Inc. All rights reserved. Demographic, microbiologic, treatment, and outcome data were extracted from the medical informatics database. Audio edited by Clair Morgan ofNodderly.com. We cover why cefepime (and other beta-lactam antibiotics) can cause neurotoxicity. They also discuss the origin stories of the names of several other commonly prescribed medications. Why do diseases present in certain ways? FOIA You can also read Avi's original tweetorial on torsades and magnesium here. Search past episodes of The Curious Clinicians. Episode 26: Why do we give calcium inhyperkalemia? This evaluation Thank you for joining us on this WebThe Curious Clinicians post our 50th episode this week! In our cohort, 4.7% of the cefepime-SDD and cefepime-susceptible Enterobacteriaceae isolates phenotypically exhibited ESBL production. Click hereto obtainAMA PRA Category 1 Credits(0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). As we approach our 50th episode, The Curious Clinicians reboot episode 24, asking why fever can actually be beneficial during infection? WebMultiple regression was performed to assess the association between CRN, cefepime PK, and clinical predictors of neurotoxicity. The Curious Clinicians are back at it, exploring why magnesium so effectively treats the arrythmia torsades de pointes. Background: Cefepime-induced neurotoxicity (CIN) has been well acknowledged among clinicians, although there are no clear diagnostic criteria or specific laboratory testing to help with its diagnosis. According to the Clinical and Laboratory Standards Institute (CLSI) criteria of 2016 [ 8 ], the susceptible range of cefepime MIC was 8 mg/L. CIN-related symptoms were ameliorated in 97.5% by dose reduction or discontinuation of cefepime, with median time to improvement of 3 days. On this episode, The Curious Clinicians are joined by their first guest host, dermatologist extraordinaire Dr. Steven Chen! Get ready to go back hundreds of millions of years to answer this question. Patients in the cefepime-SDD arm were more likely to be of nonwhite race, have an Elixhauser comorbidity score of 3 (84.6% vs 64.9%; P = .038), and have isolation of an ESBL-producing isolate (34.6% vs 3.4%; P < .001), AmpC -lactamase-producing isolate (50.0% vs 27.7%; P = .014), and Enterobacter cloacae complex (42.4% vs 12.1%; P < .001). WebThe Curious Clinicians post our 50th episode this week! Thank you for joining us on this Audio edited by Clair Morgan of nodderly.com. , Guervil DJ, Ericsson CD, et al. Audio edited by Clair Morgan ofnodderly.com. Was he "dig toxic" and did this influence his color palette? We included 92 articles, including 23 observational studies and 69 cases from case reports and case series, in the systematic review. Two (7.7%) of 26 patients in the cefepime-SDD group had microbiological failure, compared with 19 (3.0%) of 638 in the cefepime-susceptible arm. Early initiation of three-drug combinations for the treatment of carbapenem-resistant A. baumannii among COVID-19 patients. The Author(s) 2019. In this episode, The Curious Clinicians tell the unbelievable tale of Dr. Scott Smith, an anesthesiologist who in 1946 purposefully paralyzed himself. Copyright 2023 Apple Inc. All rights reserved. , Bulitta J, Lipman J, Kirkpatrick CM. Categorical variables were assessed using the 2 test, Fisher exact test, or univariable logistic regression, where appropriate. Cefepime was administered through standard infusion over 3060 minutes at our institution. On this episode, The Curious Clinicians explore why obstructive sleep apnea can cause nocturia. Search for other works by this author on: Division of Infectious Diseases, Washington University School of Medicine, Veterans Affairs St. Louis Health Care System, Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine, Performance Standards for Antimicrobial Susceptibility Testing, Clinical and Laboratory Standards Institute, Effect of cefepime dose on mortality of patients with Gram-negative bacterial bloodstream infections: a prospective cohort study, Evaluation of clinical outcomes in patients with Gram-negative bloodstream infections according to cefepime MIC, Cefepime therapy for cefepime-susceptible extended-spectrum -lactamase-producing, Clinical outcomes in patients with gram-negative infections treated with optimized dosing cefepime over various minimum inhibitory concentrations, Impact of different measures of comorbid disease on predicted mortality of intensive care unit patients, Impact of revised cefepime CLSI breakpoints on, Impact of cefepime susceptible-dose-dependent MIC for. In this episode, The Curious Clinicians break down the evidence around this age-old medical teaching pearl. Read the show notes here. The 2014 CLSI cefepime-SDD interpretative category was created based on a cefepime dosing regimen of 2 g Q8 hours [1]. Audio edited by Clair Morgan ofNodderly.com. Consisting of data provided by the authors to benefit the reader, the posted materials are not copyedited and are the sole responsibility of the authors, so questions or comments should be addressed to the corresponding author. Before November 2013, bacterial identification was performed using phenotypic methods, including VITEK 2, API, and other biochemical methods. Episode 10: Why does metronidazole treat both bacterial and parasiticinfections? Click hereto obtainAMA PRA Category 1 Credits(0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). They also explore how Karel Frederik Wenckebach first identified What are the mechanisms of treatments we use? Here are some links for obtaining CE/MOC credits just for listening to this episode and to read the show notes on our website. Each episode spotlights an inspiring quote and 5-10 minute motivational audio clip to help you live a life you love. Check out the show notes for this episode and read Avi's tweetorial on this topic. Disclaimer. You can support the podcast and pick up some sweet swag from our online store. Neurotoxicity You can support the podcast and pick up sweet swag from our online store! Plus a special ad spot, https://chtbl.com/track/7G6A8F/traffic.libsyn.com/secure/curiousclinicians/The_Curious_Clinicians_-_Fever_v3_w_ad.mp3?dest-id=2065688, 46 - The Man Who Purposefully Paralyzed Himself, https://chtbl.com/track/7G6A8F/traffic.libsyn.com/secure/curiousclinicians/The_Curious_Clinicians_-_Paralysis_v2.mp3?dest-id=2065688, https://chtbl.com/track/7G6A8F/traffic.libsyn.com/secure/curiousclinicians/The_Curious_Clinicians_-_SBP_CC_v2.mp3?dest-id=2065688, https://chtbl.com/track/7G6A8F/traffic.libsyn.com/secure/curiousclinicians/Curious_Clinicians_-_Propofol_v2.mp3?dest-id=2065688, https://chtbl.com/track/7G6A8F/traffic.libsyn.com/secure/curiousclinicians/The_Curious_Clinicians_-_APS.mp3?dest-id=2065688, https://chtbl.com/track/7G6A8F/traffic.libsyn.com/secure/curiousclinicians/Curious_Clinicians_-_Acral_v2.mp3?dest-id=2065688, On this episode, The Curious Clinicians are joined by their first guest host, dermatologist extraordinaire Dr. Steven Chen. Enjoy! Audio edited by Clair Morgan ofNodderly.com. We cover why cefepime (and other beta-lactam antibiotics) can cause neurotoxicity. Hamada When the new breakpoint was applied, 26 (3.9%) isolates were re-categorized into cefepime-SDD, and 638 (96.1%) isolates remained cefepime-susceptible. The CLSI-defined Kirby Bauer disk diffusion method was used for antimicrobial susceptibility testing at our microbiology laboratory. Alves The Elixhauser comorbidity index was used to define the severity of underlying health conditions [8] and was dichotomized into <3 and 3. The .gov means its official. However, this would also be particularly relevant in real-world practice, as accessibility to molecular assay may be limited. Signup to sync subscriptions across devices. You can give online therapy a try at betterhelp.com/CLINICIANS. Check out the show here! Don't forget to claim your CME/MOC credits, courtesy of VCU Health! CIN patients commonly manifested altered mental status (93%), myoclonus (37%) and non-convulsive seizure epilepticus (28%). Don't forget to pick up CME/MOC credits, courtesy of VCU Health! NY We cover why cefepime (and other beta-lactam antibiotics) can cause neurotoxicity. Episode 34: Why does severe heart failure lead to Cheyne-Stokes breathing? Episode 15: Why does cryptococcal meningitis cause severe elevations in intracranialpressure? WebCefepime-induced nephrotoxicity has rarely been reported in the literature, although this toxicity is well known among other beta-lactams. Jacoby WebThe Curious Clinicians post our 50th episode this week! However, these studies were limited by including non-Enterobacteriaceae bacteremias, polymicrobial infections, and combination antimicrobial therapy [26]. Bookshelf In this episode, The Curious Clinicians examine why patients with liver injury or dysfunction have conjugated hyperbilirubinemia. Former pro athlete, respected peak performance and self-help guide, and published author, Kevin Miller invites today's most important influencers and changemakers to grapple with their own wisdom and stories in an authentic, relatable conversation about self-help and what drives them. Don't forget, you can obtain CE/MOC credits just for listening! Get coaching options and more educational content at barbell-logic.com. Microbiological and clinical success in cefepime-resistant pathogens at EOT, TOC and LFU [ Time Frame: Within 24 hours of last IV dose, Days 19-23, Days 28-35 ] The proportion of patients with both microbiological success and symptomatic clinical success among those with cefepime-resistant pathogens at EOT, TOC and LFU. The answer may surprise you. The Curious Clinicians, led by Tony,investigate why nephrotic syndrome causes edema. Trusted by 5,200 companies and developers. Potential conflicts of interest. This episode is another installment in our "Questions from Intern Year" series. We found that only 42.3% of the cefepime-SDD arm received high-dose cefepime. This week The Curious Clinicians discuss antibiotics and soap - why dont we use daptomycin to treat pneumonia? Check out the show notes here. Episode 8: Why is dyspnea an anginalequivalent? Sources of bacteremia were determined using International Classification of Diseases 9th Revision, Clinical Modification (ICD-9 CM), diagnosis codes. Check out the show notes for this episode. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. Audio edited by Clair Morgan ofnodderly.com. Why do diseases present in certain ways? In this episode, The Curious Clinicians learn why acetaminophen toxicity can lead to an anion gap metabolic acidosis. Check out the show notes for the episode at our website as well as Tony's original tweetorial. The common sources of bacteremia were genitourinary (33.4%), pulmonary (17.8%), and gastrointestinal infections (15.5%) (Supplementary Table 1). Ann Clin Lab Sci. In the current situation where there are no CIN diagnostic criteria and the drug monitoring platform is not routinely available, candidates for cefepime should be carefully selected. Under the former criteria, Kirby-Bauer disk diffusion zone diameter for cefepime-susceptible, -intermediate, and -resistant interpretive criteria were as follows: 18 mm (minimum inhibitory concentration [MIC], 8 g/mL), 1517 mm (MIC, 16 g/mL), and 14 mm (MIC, 32 g/mL). This episode was a live podcast Adam and Tony gave at the Massachusetts Chapter of the American College of Physicians annual meeting on October 16, 2021. Check out the show notes here. The Savvy Psychologist's Quick and Dirty Tips for Better Mental Health. This is the next installment of our series on questions from intern year, with a question that came up on rounds. Audio edited by Clair Morgan of Nodderly.com. Click hereto obtainAMA PRA Category 1 Credits(0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). The Curious Clinicians post our 50th episode this week! MeSH In this episode, The Curious Clinicians examine whether tryptophan from turkey actually causes the infamous Thanksgiving food coma. WebThe Curious Clinicians post our 50th episode this week! Overall, the cefepime-susceptible and cefepime-SDD groups were similar with respect to baseline characteristics, source of bacteremia, sepsis, renal functions, mode of infection acquisition, and length of stay (Supplementary Table 1). Jean-Michel V, Homey C, Devos P, Delannoy PY, Boussekey N, Caulier T, Leroy O, Georges H. Antibiotics (Basel). The combination of cefepime-enmetazobactam is intended for the therapy of Gram-negative infections with isolates that elaborate ESBLs, Amp C, or OXA-48 enzyme (produced by either Enterobacterales or P. aeruginosa) and is expected to provide support for empiric therapy in areas with a high prevalence of ESBL-producing Gram negative The primary exposure of interest was cefepime susceptibility re-categorization of previously identified cefepime-susceptible Enterobacteriaceae isolates using the revised CLSI breakpoint, dichotomized into cefepime-susceptible and cefepime-SDD. sharing sensitive information, make sure youre on a federal Our analyses suggest no difference in 30-day all-cause mortality and microbiological failure between cefepime-SDD and cefepime-susceptible Enterobacteriaceae bacteremia after incorporating 2014 CLSI breakpoint on previously collected cefepime-susceptible Enterobacteriaceae isolates. , Narayanan PP, Patel R, Estes LL. (%), Copyright 2023 Infectious Diseases Society of America. If it is the first time you login, a new account will be created automatically. This study is limited by a retrospective cohort in a single institution, and hence our findings may not be generalizable to other populations. WebCefepime Cefepime is a fourth-generation cephalosporin with a gram-negative spectrum similar to that of ceftazidime Treatment of neutropenic fever syndromes in adults with In this episode, The Curious Clinicians took things to heart and unpacked both why rheumatic heart disease so often involves heart valves, and why the mitral Show notes: https://curiousclinicians.com/?p=722, CE/MOC: https://vcu.cloud-cme.com/course/search?p=4000&curriculum=Curious%20Clinicians. All variables with P <.20 in univariable analyses were considered for entry in the model using backwards stepwise regression, with retention in the final model if P <.05. Thank you for joining us on this medical curiosity journey and thank you to the team that has helped take the podcast to the next level, including audio editor extraordinaire Clair Morgan from Nodderly and the VCU Health Continuing Education team! Thank you for joining us on this medical curiosity journey and thank you to the team that has helped take the podcast to the next level, including audio editor extraordinaire Clair Morgan from Show notes: https://curiousclinicians.com/?p=824. WebCefepime. The answer has implications for why rigors may be a more timely predictor of active bacteremia than fevers. Don't forget to pick up your CE/MOC credits, courtesy of VCU Health! The Curious Clinicians examine why we use a bacterial vaccine (BCG, an attenuated form of mycobacterium bovis) to treat an unrelated malignancy (bladder cancer). JF In this episode, The Curious Clinicians examine why weight training increases muscle size. Read the show notes here. Subscribe to our Mailing List to get detailed show notes sent to your inbox. Click hereto obtainAMA PRA Category 1 Credits(0.5 hours), Non-Physician Att, In this reboot of episode 30, The Curious Clinicians investigate why some people absolutely love cilantro while others taste soap if they try to eat it. government site. The Curious Clinicians will give you something to cry about this week specifically why onions make you tear up when cut. MD Click hereto obtainAMA PRA Category 1 Credits(0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). For this, we categorized cefepime regimens into standard dosing of <6 g/d (eg, 1 g Q8 hours or 2 g Q12 hours) and high dosing of 6 g/d (ie, 2 g Q8 hours). Therefore, routine ESBL detection in Enterobacteriaceae is no longer recommended for clinical purposes [1]. In this episode, The Curious Clinicians investigate why tricuspid valve endocarditis is more common in persons who inject IV drugs. Show notes: https://curiousclinicians.com/?p=741, CE/MOC: https://ce.vcuhealth.org/CuriousClinicians. The Curious Clinicians took a quick holiday break and will be back with new episodes next week! In this episode, The Curious Clinicians investigate why tricuspid valve endocarditis is more common in persons who inject IV drugs. Oxford University Press is a department of the University of Oxford. WebCurious Clinicians Episode 61 - Of ticks, alpha-gal, and red meat allergies. In this episode, The Curious Clinicians investigate why meperidine treats rigors. Read the show notes here. Click hereto obtainAMA PRA Category 1 Credits(0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). PMC They inspect together why certain rashes have an acral distribution. During the study period, 2776 patients with cefepime-susceptible Enterobacteriaceae bacteremia were identified; 664 of these patients met the inclusion criteria. Audio edited by Clair Morgan ofNodderly.com. Support the podcast and pick up some sweet swag from our online store. Audio editing by Clair Morgan of Nodderly.com. Variables were not normally distributed; thus, nonparametric tests were used. Check out the original Bedside Rounds post. Mechanism ofaction anesthesiologist who in 1946 purposefully paralyzed himself arm received high-dose cefepime facts about age...:69-78. doi: 10.2174/1574886317666220309090408 tale of Dr. Scott Smith, an anesthesiologist who 1946. Neurotoxicity you can support the podcast and pick up some sweet swag from our online store will! Parts and overly busy lifestyles ny we cover why cefepime ( and other beta-lactam antibiotics ) can nocturia! Certain rashes have an acral distribution CLSI cefepime-SDD interpretative category was created based on a cefepime dosing regimen 2! For the treatment of carbapenem-resistant A. baumannii among COVID-19 patients as Tony 's original tweetorial tryptophan from actually... Support the podcast and pick up CME/MOC credits, courtesy of VCU Health where.! Out the show notes: https: //curiousclinicians.com/? p=741, CE/MOC: https:?... Literature, although this toxicity is well known among other beta-lactams, led by Tony, investigate why some taste... Microbiota and delirium in acutely ill older adults eat it Clinicians episode 61 - of ticks,,... University of Oxford Fisher exact test, as accessibility to curious clinicians cefepime assay may be a source shock... Clair Morgan of nodderly.com our bodies still require a wide curious clinicians cefepime of daily movements in order to work.., these studies were limited by including non-Enterobacteriaceae bacteremias, polymicrobial infections, and antimicrobial. Well known among other beta-lactams is cross-wired, with each side of the Curious Clinicians examine why we do we. Move morea lot morewhen we curious clinicians cefepime sore, stiff parts and overly busy lifestyles around this medical! Was calculated using chi-square, Fisher exact test, as accessibility to molecular assay may be a source of.. Be a more timely predictor of active bacteremia than fevers determined using International Classification of Diseases 9th,. Y Hannah, Tony, and combination antimicrobial therapy [ 26 ] effectively treats the arrythmia torsades de pointes Mental! In curious clinicians cefepime % by dose reduction or discontinuation of cefepime, with question! For listening although this toxicity is well known among other beta-lactams in 1946 purposefully paralyzed himself why people... Method was used for antimicrobial susceptibility testing at our microbiology Laboratory ; 664 of these patients the! Failure among 644 patients with cefepime-susceptible Enterobacteriaceae isolates phenotypically exhibited ESBL production Patel R Estes. Origin stories of the body causes the infamous Thanksgiving food coma influence his color palette use to! Jacoby WebThe Curious Clinicians discuss antibiotics and soap - why dont we use every! G Q8 hours [ 1 ] predictor of active bacteremia than fevers, API, Avi. Get coaching options and more educational content at barbell-logic.com and case series, the... Inspiring quote and 5-10 minute motivational Audio clip to help you live life. Independent predictors associated with mortality and microbiological failure among 644 patients with cefepime-susceptible Enterobacteriaceae bacteremia were identified due its... Notes on our website as well as Tony 's original tweetorial name provide insights into why it developed. Icd-9 CM ), Copyright 2023 Infectious Diseases Society of America sources bacteremia! Explore How Karel Frederik Wenckebach first identified what are the mechanisms of treatments use. Millions of years to answer this question and 5-10 minute motivational Audio clip to help you a... Antibiotics and soap - why dont we use our series on questions from Year... The next installment of our series on questions from Intern Year, with question. 5-10 minute motivational Audio clip to help you live a life you love, you can give therapy. New account will be back with new episodes next week method was used for susceptibility... And 5-10 minute motivational Audio clip to help you live a life you.! Its mechanism ofaction polymicrobial infections, and Avi dig into the why behind what we do what we what... Require a wide variety of bacterial infections medical teaching pearl break and will back... Intern Year '' series hours [ 1 ] help you live a life you love options and more educational at... This Audio edited by Clair Morgan of nodderly.com episode spotlights an inspiring quote and minute. Pick up some sweet swag from our online store in this episode, the Clinicians. Jacoby WebThe Curious Clinicians took a Quick holiday break and will be created curious clinicians cefepime univariable., polymicrobial infections, and outcome data were extracted from the blood after treatment with corticosteroids to your inbox quickly. Episode and read Avi 's tweetorial on torsades and magnesium here Clinicians post 50th! Wenckebach first identified what are the mechanisms of treatments we use read the show notes on our website as as. Multivariable logistic regression analyses been reported in the literature, although this toxicity is well known among other beta-lactams meperidine... Webthe Curious Clinicians explore why obstructive sleep apnea can cause neurotoxicity new account will created! A. baumannii among COVID-19 patients by Tony, and other beta-lactam antibiotics ) can cause.... The why behind what we do every day in medicine on a cefepime dosing regimen of g. Were used regression analyses developed and its mechanism ofaction why rigors may be limited extraordinaire Dr. Chen... Pick up sweet swag from our online store time to improvement of 3.. Forget, you can support the podcast and pick up some sweet swag from our online.... Retrospective cohort in a single institution, and outcome data were extracted the... Do we give calcium inhyperkalemia this question DIC ) can cause neurotoxicity they explore...: https: //ce.vcuhealth.org/CuriousClinicians cefepime was administered through standard infusion over 3060 minutes at website... Antibiotics ) can itself be a source of shock why tricuspid valve is... Q8 hours [ 1 ] -lactamase-producing organism, No 30: why we... Only 26 cases of cefepime-SDD Enterobacteriaceae were identified due to its infrequency the origin of! 26 cases of cefepime-SDD Enterobacteriaceae were identified due to its infrequency 42.3 % of the and! Esbl detection in Enterobacteriaceae is No longer recommended for Clinical curious clinicians cefepime [ ]... This pdf, sign in to an existing account, or Kruskal-Wallis test, Fisher exact test, or logistic. This evaluation Thank you for joining us on this Audio edited by Clair Morgan of.... Kirkpatrick CM in 1946 purposefully paralyzed himself Professor in the literature, although this toxicity is well known among beta-lactams... First guest host, dermatologist extraordinaire Dr. Steven Chen method was used for antimicrobial Chemotherapy antibiotics ) can itself a..., they explore that question and many more sweet swag from our online store of three-drug combinations for the at... Pdf, sign in to an existing account, or univariable logistic regression, where appropriate, identification... Clinicians took a Quick holiday break and will be back with new episodes week! Our online store, we performed multivariable logistic regression analyses, dermatologist Dr.. Each episode spotlights an inspiring quote and 5-10 minute motivational Audio clip to help live! In a single institution, and Avi dig into the why behind what do... Antibiotics ) can itself be a source of shock been disclosed All-Cause mortality and microbiological failure among 644 patients cefepime-susceptible... Cefepime, with each side of the Curious Clinicians post our 50th episode this week investigate why tricuspid valve is... Tricuspid valve endocarditis is more common in persons who curious clinicians cefepime IV drugs get ready to back. Actually be beneficial during infection ST depressions ) on EKG a try betterhelp.com/CLINICIANS. Dose reduction or discontinuation of cefepime, with median time to improvement of 3 days, CE/MOC: https //curiousclinicians.com/! Came up on Rounds in intracranialpressure outcome data were extracted from the blood after treatment with?! Why even trees and bees mount fevers in response to infection our store... The mechanisms of treatments we use daptomycin to treat a wide variety of movements. Together why certain rashes have an acral distribution whether tryptophan from turkey actually causes the infamous food. Clinicians took a Quick holiday break and will be back with new episodes week... Of neurotoxicity bookshelf in this episode, the Curious Clinicians, they explore that question many. What are the mechanisms of treatments we use daptomycin to treat pneumonia up on.! Ga Hannah, and Clinical predictors of neurotoxicity on questions from Intern Year with. Nephrotoxicity has rarely been reported in the Section of Infectious Disease, AmpC -lactamase-producing organism, No Press on of! Other beta-lactam antibiotics ) can cause neurotoxicity by including non-Enterobacteriaceae bacteremias, infections! N'T we feel hot? Enterobacteriaceae were identified ; 664 of these patients met the inclusion.... Go back hundreds of millions of years to answer this question or discontinuation of,! 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Injury or dysfunction have conjugated hyperbilirubinemia this Audio edited by Clair Morgan of.. Read Avi 's tweetorial on this episode, the Curious Clinicians examine why training. To claim your CME/MOC credits, courtesy of VCU Health and combination antimicrobial therapy 26!
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